|
|||||
|
|
hnRNP A1 interacts with the genomic and subgenomic RNA promoters of Sindbis virus and is required for the synthesis of G and SG RNA |
|
| Authors: | Hongxing Gui Chi-Wei Lu Sandra Adams Victor Stollar Mei-Ling Li |
| Institution: | (1) Department of Physiology & Biophysics, Molecular Genetics, Microbiology & Immunology, UMDNJ-Robert Wood Johnson Medical School, 08854 Piscataway, NJ, USA;(2) Department of OB/GYN, UMDNJ-Robert Wood Johnson Medical School, 08854 Piscataway, NJ, USA;(3) Department of Biology & Molecular Biology, Montclair State University, 07043 Montclair, NJ, USA;(4) Department of Molecular Genetics, Microbiology & Immunology, UMDNJ-Robert Wood Johnson Medical School, 08854 Piscataway, NJ, USA;(5) The Cancer Institute of New Jersey, 08903 New Brunswick, NJ, USA |
| Abstract: | BackgroundSindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttles between the nucleus and the cytoplasm. Our recent studies found that hnRNP A1 relocates from nucleus to cytoplasm in Sindbis virus (SV)-infected cells. hnRNP A1 binds to the 5' UTR of SV RNA and facilitates the viral RNA replication and translation. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |