Crosstalk between mitochondria and peroxisomes |
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Authors: | Jean Demarquoy Fran?oise Le Borgne |
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Affiliation: | Jean Demarquoy, Françoise Le Borgne, Université de Bourgogne, UFR SVTE, 21000 Dijon, France |
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Abstract: | Mitochondria and peroxisomes are small ubiquitous organelles. They both play major roles in cell metabolism,especially in terms of fatty acid metabolism,reactive oxygen species(ROS) production,and ROS scavenging,and it is now clear that they metabolically interact with each other. These two organelles share some properties,such as great plasticity and high potency to adapt their form and number according to cell requirements. Their functions are connected,and any alteration in the function of mitochondria may induce changes inperoxisomal physiology. The objective of this paper was to highlight the interconnection and the crosstalk existing between mitochondria and peroxisomes. Special emphasis was placed on the best known connections between these organelles:origin,structure,and metabolic interconnections. |
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Keywords: | Peroxisome Mitochondrion Beta-oxidation Reactive oxygen species Dynamic Fatty acids |
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