Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists |
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| Authors: | Palani Anandan Dugar Sundeep Clader John W Greenlee William J Ruperto Vilma Duffy Ruth A Lachowicz Jean E |
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| Affiliation: | Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. anandan.palani@spcorp.com |
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| Abstract: | Low molecular weight amide derivatives were synthesized and evaluated as M(2) receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M(2) receptor antagonists with structural features different from our clinical candidate 1. |
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