Proffered Papers 10.30–11.15 Monday 15 September 2003 3 5 year outcome of women with borderline and mild dyskaryosis smears 3 5 year outcome of women with borderline and mild dyskaryosis smears

Aims

• 1 To identify the outcome status of women with borderline and mild dyskaryosis smears.
• 2 To determine whether the presence or absence of koilocytosis influences the outcome status.
• 3 To identify the proportion of women with borderline smears showing koilocytosis.

Materials and methods Borderline and mild dyskaryosis cervical smears diagnosed during January to March 1997 were identified from the laboratory database. Each slide was reviewed by two researchers independently, who then agreed a final consensus diagnosis. All slides were classified according to the presence or absence of koilocytosis. Slides were excluded from the study if the review diagnosis was negative, inadequate or high‐grade dyskaryosis. The outcome status was classified according to the worst lesion identified histologically and/or cytologically during the 5‐year follow‐up period. Results 1974 women were identified with borderline or mild dyskaryosis cervical smears of which 1597 were included in the study. Table 1 shows the outcome status of these women.

Table 1. . The outcome status of these women

Cytology	Outcome status
	Negative (%)	Low‐grade (%)	High‐grade (%)
Borderline	68	19	13
Mild dyskaryosis	46	26	28

Table 2 shows the outcome of women with borderline and mild dyskaryosis smears with or without koilocytosis.

Table 2. The outcome of women with borderline and mild dyskaryosis smears with or without koilocytosis

Koilocytosis	Outcome status
	Negative (%)	Low‐grade (%)	High‐grade (%)
Present	58	22	20
Absent	61	21	18

Table 3 shows the proportion of borderline and mild dyskaryosis cervical smears with or without koilocytosis.

Table 3. The proportion of borderline and mild dyskaryosis cervical smears with or without koilocytosis

Cytology	Koilocytosis present (%)	Koilocytosis absent (%)
Borderline	24	76
Mild dyskaryosis	34	66

Conclusions

• 1 Sixty‐eight per cent of women with a borderline cervical smear had a normal outcome.
• 2 Thirteen per cent of women with a borderline cervical smear developed a high‐grade lesion.
• 3 The presence or absence of koilocytosis in borderline and mild dyskaryosis cervical smears does not appear to affect the outcome status of these women.
• 4 Twenty‐four per cent of smears showing borderline nuclear changes were found to have koilocytosis.