A highly selective method for 11 beta-OH protection of steroidal 11 beta, 17 alpha-diols |
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| Authors: | Glossop Paul A Hoogenraad Marcel Peakman Torren M Roberts Dannielle F |
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| Institution: | Pfizer Global R & D, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom. |
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| Abstract: | A highly selective method to protect the 11 beta-OH position of steroid (1) has been developed. This is achieved via double silyl protection of the 11 beta, 17 alpha-diol, followed by selective desilylation of the 17 alpha-OH under basic conditions without the need for a fluoride source. |
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