Haplotypes versus genotypes on pedigrees |
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Authors: | Bonnie B Kirkpatrick |
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Institution: | (1) Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, CA 94720-1776, USA;(2) International Computer Science Institute, 1947 Center St. Suite 600, Berkeley, CA 94704, USA |
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Abstract: | Background Genome sequencing will soon produce haplotype data for individuals. For pedigrees of related individuals, sequencing appears
to be an attractive alternative to genotyping. However, methods for pedigree analysis with haplotype data have not yet been
developed, and the computational complexity of such problems has been an open question. Furthermore, it is not clear in which
scenarios haplotype data would provide better estimates than genotype data for quantities such as recombination rates. |
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