Morphological and functional alterations in adult boar epididymis: Effects of prenatal and postnatal administration of flutamide |
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Authors: | Marta Lydka Ilona Kopera-Sobota Malgorzata Kotula-Balak Katarzyna Chojnacka Dorota Zak Barbara Bilinska |
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Institution: | (1) Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland |
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Abstract: | Background The dynamic cross-talk between epididymal cells is hormonally regulated and, in part, through direct cell-to-cell interactions.
To date, no information is available regarding possible impact of anti-androgens on the proteins involved in the gap junctional
communication within the boar epididymis. Thus, a question arised whether prenatal or postnatal exposure to an anti-androgen
flutamide alters the expression of gap junction protein - connexin43 (Cx43) and androgen receptor (AR) expression in the caput,
corpus and cauda epididymis and leads to delayed effects on morphology and function of adult pig epididymis. |
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