Probabilistic analysis of probe reliability in differential gene expression studies with short oligonucleotide arrays |
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| Authors: | Lahti Leo Elo Laura L Aittokallio Tero Kaski Samuel |
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| Institution: | Helsinki Institute for Information Technology, Department of Information and Computer Science, Aalto University School of Science and Technology, PO Box 15400, FI-00076 Aalto, Finland. leo.lahti@iki.fi |
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| Abstract: | Probe defects are a major source of noise in gene expression studies. While existing approaches detect noisy probes based on external information such as genomic alignments, we introduce and validate a targeted probabilistic method for analyzing probe reliability directly from expression data and independently of the noise source. This provides insights into the various sources of probe-level noise and gives tools to guide probe design. |
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