Molecular characterization of resistance to Rifampicin in an emerging hospital-associated Methicillin-resistant Staphylococcus aureus clone ST228, Spain |
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| Authors: | Virginie Mick M Angeles Domínguez Fe Tubau Josefina Liñares Miquel Pujol Rogelio Martín |
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| Institution: | (1) Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, University of Barcelona, Feixa Llarga s/n 08907 Hospitalet de Llobregat, Barcelona, Spain;(2) CIBERES (CIBER de Enfermedades Respiratorias), ISCIII, Madrid, Spain;(3) Infectious Diseases Department, Hospital Universitari de Bellvitge, University of Barcelona, IDIBELL, Barcelona, Spain |
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| Abstract: | Background Methicillin-resistant S. aureus (MRSA) has been endemic in Hospital Universitari de Bellvitge, Barcelona, since 1990. During the 1990-95 period the Iberian
clone (ST-247; SCCmec-I) was dominant. Isolates of clonal complex 5 (ST-125; SCCmec-IV) gradually replaced the Iberian clone from 1996 to 2003. A new multiresistant MRSA phenotype showing rifampicin resistance
emerged in 2004 and rapidly increased from 25% in 2004 to 45% in 2006. The aims of this study were i) the molecular characterisation
of rifampicin resistant MRSA isolates, ii) the study of the rifampicin resistance expression by disk diffusion, microdilution
and E-test, and iii) the analysis of the rpoB gene mutations involved in rifampicin resistance. |
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