Syntheses and studies of amamistatin B analogs reveals that anticancer activity is relatively independent of stereochemistry, ester or amide linkage and select replacement of one of the metal chelating groups |
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| Authors: | Wu Chunrui Miller Patricia A Miller Marvin J |
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| Affiliation: | Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA |
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| Abstract: | A series of analogs of the amamistatin natural products was designed and synthesized to facilitate additional anticancer structure-activity relationships. The results indicate that the anticancer activity is relatively independent of stereochemistry, ester or amide linkage and replacement of the oxazoline/oxazole based iron-binding group with a catechol. |
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| Keywords: | Amamistatins Anti-cancer Structure-activity relationships (SAR) Design Syntheses Studies Iron binding natural products |
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