The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease |
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| Affiliation: | 1. Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States;2. Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, United States;3. Center for Biomedical Research Support, Biological Mass Spectrometry Facility, The University of Texas at Austin, Austin, TX 78712, United States |
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| Abstract: | The Saccharomyces cerevisiae APNI gene, encoding the bifunctional DNA repair enzyme apurinic/apyrimidinic (AP) endonuclease/3′-repair diesterase, was used as a probe to isolate a gene homolog, CeAPN1, from a Caenorhabditis elegans cDNA library. The CeAPN1 gene is predicted to encode a protein 30 kDa in size, which shares 40.4% and 44.9% identity at the amino acid level with, respectively, S. cerevisiae Apnl and Escherichia coli endonuclease IV. We suggest that CeApn1 protein is a member of the endonuclease IV family of DNA repair enzymes. |
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