Insights into T‐cell dysfunction in Alzheimer's disease |
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| Authors: | Linbin Dai Yong Shen |
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| Institution: | 1. Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Sciences and Technology of China, Hefei China ; 2. Neurodegenerative Disease Research Center, University of Science and Technology of China, Hefei China ; 3. Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei China |
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| Abstract: | T cells, the critical immune cells of the adaptive immune system, are often dysfunctional in Alzheimer''s disease (AD) and are involved in AD pathology. Reports highlight neuroinflammation as a crucial modulator of AD pathogenesis, and aberrant T cells indirectly contribute to neuroinflammation by secreting proinflammatory mediators via direct crosstalk with glial cells infiltrating the brain. However, the mechanisms underlying T‐cell abnormalities in AD appear multifactorial. Risk factors for AD and pathological hallmarks of AD have been tightly linked with immune responses, implying the potential regulatory effects of these factors on T cells. In this review, we discuss how the risk factors for AD, particularly Apolipoprotein E (ApoE), Aβ, α‐secretase, β‐secretase, γ‐secretase, Tau, and neuroinflammation, modulate T‐cell activation and the association between T cells and pathological AD hallmarks. Understanding these associations is critical to provide a comprehensive view of appropriate therapeutic strategies for AD. |
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| Keywords: | Alzheimer''s disease hallmarks neuroinflammation risk factors T cells |
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