Hunter syndrome in Jews in Israel: further evidence for prenatal selection favoring the Hunter allele |
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Authors: | J Zlotogora T Schaap M Zeigler G Bach |
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Institution: | (1) Department of Human Genetics, Hadassah Medical Center, Hebrew University, P. O. B. 12000, 91120 Jerusalem, Israel |
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Abstract: | Summary Among all the Jewish families with Hunter patients in Israel, 10 were Ashkenazi or Moroccan in origin. In those families, there was a paucity of new mutations. In addition, a significant deviation of the segregation ratio between the Hunter gene and the normal allele was demonstrated among the offspring of heterozygous mothers or siblings of affected children in these families. These results confirm and extend our previous observations suggesting selection in favor of the X chromosome carrying the Hunter allele among Ashkenazi and Moroccan Jews. |
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