1. Division of Psychiatry, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex, HA1 3UJ, U.K.;2. Division of Radioisotopes, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex, HA1 3UJ, U.K.
Abstract:
A high striatum: cerebellum ratio of 77Br-p-bromospiperone (77Br-BrSp) was observed in rat brain following tail vein injection of the drug. Striatal 77Br-BrSp was stereospecifically displaced by the isomers of flupenthixol. After chronic haloperidol administration striatal dopamine receptor supersensitivity was demonstrated both by increased 3H-spiperone binding to striatal membranes in vitro and by increased striatal 77Br-BrSp content. These results confirm and extend previous findings and enhance interest in the use of 77Br-BrSp for the in vivo assessment of central dopamine receptors in man.