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Peptidyltransferase center of ribosomes: On the mechanism of action of alkaloid lycorine |
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| Authors: | Marina Kukhanova Ljubov Victorova Alexander Krayevsky |
| Abstract: | The molecular mechanism of action of the alkaloid lycorine has been revised. According to our results, lycorine inhibits the binding of CACCA-Leu←Ac to the donor site of the peptidyltranferase center of wheat-germ ribosomes, whereas the transpeptidation reaction in the system with the minimal model donor is not inhibited. The equilibrium constant of CACCA-Leu←Ac to the donor site of 80 S ribosomes is measured. |
| Keywords: | Alkaloid lycorine 80 S ribosome Mechanism of action Association constant Peptidyltranferase center |
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