| 牙龈紫质单胞菌内毒素对成纤维细胞和牙龈组织的侵入及损害 |
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| 引用本文： | 陈莉丽,朱仲珍,赵丹萍.牙龈紫质单胞菌内毒素对成纤维细胞和牙龈组织的侵入及损害[J].中国微生态学杂志,1999,11(1):16-18. |
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| 作者姓名： | 陈莉丽 朱仲珍 赵丹萍 |
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| 作者单位： | 浙江医科大学附属第二医院口腔科,310009 |
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| 摘 要： | 应用免疫组化方法证实５６０％的成年人牙周炎（ＡＰ）患者的牙龈组织的成纤维细胞中存在牙龈紫质单胞菌内毒素（Ｐｇ－ＬＰＳ），正常的牙龈组织样本无一例阳性。以免疫胶金技术发现Ｐｇ－ＬＰＳ在５ｍｉｎ内即能侵入体外培养的小鼠成纤维细胞，至６０ｍｉｎ时可在细胞核内检出Ｐｇ－ＬＰＳ。Ｐｇ－ＬＰＳ检测阳性的小鼠成纤维细胞和ＡＰ患者牙龈组织的成纤维细胞的可出现相似的内质网扩张、膜旁核糖体颗粒脱落、线粒体的外膜或嵴消失等超微结构病变。实验结果表明，Ｐｇ－ＬＰＳ是ＡＰ的主要致病因子之一。
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| 关 键 词： | 牙龈紫质单胞菌 内毒素 牙周炎 超微结构病变 |
| 修稿时间： | 1998-05-22 |
INVASION AND DAMAGE TO MOUSE FIBROBLAST AND HUMAN GINGIVAL TISSUE BY ENDOTOXIN OF PORPHYROMONAS GINGIVALIS |
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| Chen Lili,et al..INVASION AND DAMAGE TO MOUSE FIBROBLAST AND HUMAN GINGIVAL TISSUE BY ENDOTOXIN OF PORPHYROMONAS GINGIVALIS[J].Chinese Journal of Microecology,1999,11(1):16-18. |
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| Authors: | Chen Lili |
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| Institution: | Chen Lili,et al. Department of Stomatology,the Second Affiliated Hospital of Zhejiang Medical University |
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| Abstract: | The endotoxin or lipopolysaccharides of Porphyromonas gingivalis(Pg-LPS) existed in the gingival samples of 56% of the patients with adult periodontitis(AP) but could not be detected in normal gingival samples by immunohisto-chemical method. Pg-LPS could invase the cytoplasm in 5 minutes and the nucleus in 60 minutes of mouse fibroblasts in vitro after Pg-LPS |
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| Keywords: | Porphyromonas gingivalis Endotoxin Periodontitis Ultrastructure pathologic change |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
