Isolation and Partial Characterization of Nucleic Acid of Influenza Virus |
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| Authors: | D. P. Nayak and M. A. Baluda |
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| Affiliation: | aDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Los Angeles, California 90024 |
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| Abstract: | The principal ribonucleic acid (RNA) component isolated from purified equine influenza virus has an approximate sedimentation coefficient (S(20,W)) of 21S in sucrose gradient containing 0.1 m NaCl. Three other components of 18S, 14S, and 8S were also detected. All the RNA components have characteristics of single-stranded RNA. The average base composition of the principal RNA components is cytosine, 22.2; adenine, 22.9; guanine, 22.3; and uridine, 32.6. There was no qualitative difference in the RNA isolated from noninfectious virus particles compared to that from infectious virions. |
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