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I Siah substrate! |
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| Authors: | Briant Douglas J Ceccarelli Derek F Sicheri Frank |
| Affiliation: | 1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada;2. Department of Medical Genetics and Microbiology, University of Toronto, 1 King''s College Circle, Toronto, Ontario, M5S 1A8, Canada |
| Abstract: | Proteins are targeted to the E3 RING ubiquitin ligase Siah through a PxAxVxP degron motif. In this issue of Structure, House et al. (2006) present the structural basis by which Siah recognizes its degron with high affinity and specificity. |
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