Stereoselective halogenation of the 16-hydroxymethyl-3-methoxy-13alpha-estra-1,3,5(10)-trien-17-ols and their solvolytic investigation |
| |
| Authors: | Wölfling János Mernyák Erzsébet Forgó Péter Schneider Gyula |
| |
| Affiliation: | Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary. |
| |
| Abstract: | The primary hydroxy functions of 16alpha-hydroxymethyl-3-methoxy-13alpha-estra-1,3,5(10)-trien-17beta-ol (3a) and 16beta-hydroxymethyl-3-methoxy-13alpha-estra-1,3,5(10)-trien-17alpha-ol (4a) were stereoselectively transformed into good leaving groups. On alkaline methanolysis of the 16-halomethyl or 16-tolylsulfonyloxymethyl derivatives, a new D-seco-13alpha-estrone derivative was obtained in high yield. |
| |
| Keywords: | Steroid Selective synthesis smallcaps" >d-Secosteroid 13α-Estrone |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
