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Fatty acid acylated antibodies against virus suppress its reproduction in cells |
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| Authors: | AV Kabanov AV Ovcharenko NS Melik-Hubarov AI Bannikov VYu Alakhov VI Kiselev PG Sveshnikov OI Kiselev AV Levashov ES Severin |
| Institution: | Department of Pharmacology, University of Edinburgh, Scotland. |
| Abstract: | A method for suppression of virus reproduction in cells using fatty acylated antiviral antibodies, which in contrast to non-modified antibodies are capable of intracellular penetration, has been suggested. The addition of stearoylated antiviral antibodies to influenza A/Chili virus-infected cells causes a 100-fold suppression of virus reproduction. Non-modified antibodies do not produce any effect on virus reproduction. |
| Keywords: | Antibody Fatty acylation Virus suppression Influenza |
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