Lack of linkage between gene(s) controlling the synthesis of the seventh component of complement and the HLA region on chromosome No. 6 in man |
| |
| Authors: | Ch Rittner W Opferkuch B Wellek H Grosse-Wilde P Wernet |
| |
| Institution: | (1) Institut für gerichtliche Medizin, Universität Bonn, Bonn, Federal Republic of Germany;(2) Lehrstuhl für Medizinische Mikrobiologie, Ruhruniversität Bochum, Bochum, Federal Republic of Germany;(3) Institut für Medizinische Mikrobiologie, Universität Mainz, Mainz, Federal Republic of Germany;(4) Institut für Hämatologie, Abteilung Immunologie, GSF München, Munich, Federal Republic of Germany;(5) DFG-Forschergruppe Leukämie und Tumortherapie Tübingen, Tübingen, Federal Republic of Germany |
| |
| Abstract: | Summary The family of an individual was studied who lacks the seventh component of complement in his serum (C7 homozygous deficiency). Both parents are C7 heterozygousdeficient. In this investigation, the following parameters were determined: complement components in functional and immunochemical tests; HLA-A,B antigens, HLA-D (MLC) determinants; the Bf system; glyoxalase I and B cell antigens. No evidence for linkage between the immunogenetic linkage group on chromosome 6 and gene(s) controlling the synthesis of the seventh component of complement was obtained. This is in accordance with the assumption that only genes controlling components of the initiating rather than the membrane attack unit of complement are linked to the HLA region. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
