Superoxide dismutase activity of the captopril-iron complex |
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Authors: | David Jay Adela Cuella Elizabeth Jay |
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Affiliation: | (1) Department of Biochemistry, State University of New York (HSCB), 450 Clarkson Avenue, 11203-2098 Brooklyn, New York, USA;(2) Departmento de Bioquimica, Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico |
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Abstract: | With an assay that generates superoxide anion radicals without the intervention of metal ions we investigated the antioxidant properties of captopril, an angiotensin-converting enzyme inhibitor with a sulfhydryl group. Under these conditions, increasing concentrations of the drug were seen not to scavenge O·2– directly. However, a combination of captopril and iron could bring about the breakdown of the superoxide anion; a result that may help to understand the free radical-scavenging properties of captopril. |
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Keywords: | captopril superoxide anion iron chelating reagent ischemia-reperfusion injury free radicals |
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