Adenoviral vectors for highly selective gene expression in central serotonergic neurons reveal quantal characteristics of serotonin release in the rat brain |
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| Authors: | Kheira Benzekhroufa Beihui Liu Feige Tang Anja G Teschemacher Sergey Kasparov |
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| Affiliation: | (1) Department of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK |
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| Abstract: | Background 5-hydroxytryptamine (5 HT, serotonin) is one of the key neuromodulators in mammalian brain, but many fundamental properties of serotonergic neurones and 5 HT release remain unknown. The objective of this study was to generate an adenoviral vector system for selective targeting of serotonergic neurones and apply it to study quantal characteristics of 5 HT release in the rat brain. |
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