A characteristic sequence of trisomies starting with trisomy 7 in benign thyroid tumors |
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Authors: | Gazanfer Belge Brita Thode Volkhard Rippe Sabine Bartnitzke Jörn Bullerdiek |
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Institution: | (1) Zentrum für Humangenetik und genetische Beratung, Universität Bremen, Leobenerstrasse ZHG, D-28359 Bremen, Germany;(2) Abteilung für Pathologie, Zentralkrankenhaus, St.-Jürgen-Strasse, D-28205 Bremen, Germany |
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Abstract: | The cytogenetic results from a series of 113 thyroid hyperplasias and adenomas are reported; 15 showed clonal karyotypic alterations. In addition to a group showing translocations involving 19q13, another subset of lesions characterized by polysomies can be found. Based on our own cases belonging to this subset and a review of the cases reported in the literature, we conclude that the characteristic feature of this group is a sequence that always starts with trisomy 7, but that sometimes even leads to chromosome numbers in the hypertriploid range. This subset of thyroid tumors may be an example of a more common genetic pathway in human solid tumors. |
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