Endocannabinoid-mediated metaplasticity in the hippocampus |
| |
Authors: | Chevaleyre Vivien Castillo Pablo E |
| |
Institution: | Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. |
| |
Abstract: | Repetitive activation of glutamatergic fibers that normally induces long-term potentiation (LTP) at excitatory synapses in the hippocampus also triggers long-term depression at inhibitory synapses (I-LTD) via retrograde endocannabinoid signaling. Little is known, however, about the physiological significance of I-LTD. Here, we show that synaptic-driven release of endocannabinoids is a highly localized and efficient process that strongly depresses cannabinoid-sensitive inhibitory inputs within the dendritic compartment of CA1 pyramidal cells. By removing synaptic inhibition in a restricted area of the dendritic tree, endocannabinoids selectively "primed" nearby excitatory synapses, thereby facilitating subsequent induction of LTP. This induction of local metaplasticity is a novel mechanism by which endocannabinoids can contribute to the storage of information in the brain. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|