Improved performance in protein secondary structure prediction by combining multiple predictions

In this paper(1) we present a novel framework for protein secondary structure prediction. In this prediction framework, firstly we propose a novel parameterized semi-probability profile, which combines single sequence with evolutionary information effectively. Secondly, different semi-probability profiles are respectively applied as network input to predict protein secondary structure. Then a comparison among these different predictions is discussed in this article. Finally, na?ve Bayes approaches are used to combine these predictions in order to obtain a better prediction performance than individual prediction. The experimental results show that our proposed framework can indeed improve the prediction accuracy.