Vitamin D Deficiency Does Not Affect The Likelihood Of Presurgical Localization In Asymptomatic Primary Hyperparathyroidism |
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| Institution: | 1. From the Division of Endocrinology, Diabetes and Metabolism, Santa Croce and Carle Hospital, Cuneo, Italy;2. Division of Nuclear Medicine, Santa Croce and Carle Hospital, Cuneo, Italy;3. Thyroid and Parathyroid Surgery, Casa di Cura “Città di Bra,” Cuneo, Italy;4. Endocrinology Service, Galeazzi Institute, IRCCS, Milan, Italy.;1. From the Xavier University of Louisiana, College of Pharmacy, New Orleans, Louisiana;2. Bristol-Myers Squibb, GHEOR CV/Met, New York, New York;3. Bristol-Myers Squibb, CORDS, New York, New York;4. Tulane University, School of Medicine, New Orleans, Louisiana;5. Tulane University, School of Public Health and Tropical Medicine, New Orleans, Louisiana.;1. From the University of Texas Medical Branch, Department of Pediatrics,;2. University of California, San Francisco, Department of Pediatrics;3. Boston University School of Medicine, Department of Pediatrics;4. University of Texas Medical Branch, Department of Preventive Medicine and Community Health;5. Stanford University Medical Center, Department of Pediatrics.;1. From the University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.;1. From the Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, India;2. Neuro Oncology group, Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai;3. Department of Neurosurgery, Seth G S Medical College and KEM Hospital, Mumbai, India. |
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| Abstract: | Objective: Vitamin D deficiency (VDD) was previously associated with larger adenoma size in primary hyperparathyroidism (PHPT), but this topic was not addressed in patients with the mild/asymptomatic form of the disease (aPHPT).Methods: We retrospectively retrieved from our series of patients affected by PHPT, 96 consecutive subjects with aPHPT in whom 25-hydroxyvitamin D (25OHD) levels had been assayed and compared those results with localizing imaging studies.Results: Twenty-five of 96 patients had VDD (25OHD <20 ng/mL), but positive ultrasound and scintigraphic studies were not different between patients with and without VDD (52.3% versus 55.7% and 42.9% versus 52.4%, respectively). Upon logistic regression analysis, after adjusting for different variables, including the presence of goiter, VDD was not an independent predictor of localization by imaging studies.Conclusion: VDD does not affect the likelihood of positive pre-operative imaging in aPHPT and the consequent surgical decisions.Abbreviations:25OHD = 25-hydroxyvitamin DaPHPT = asymptomatic primary hyperparathyroidismMIBI = Tc99m sestamibiPHPT = primary hyperparathyroidismPTH = parathyroid hormoneUS = ultrasoundVDD = vitamin D deficiency |
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