Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes |
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| Authors: | Avinash M Veerappa Sangeetha Vishweswaraiah Kusuma Lingaiah Megha Murthy Raviraj V Suresh Dinesh S Manjegowda Nallur B Ramachandra |
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| Institution: | 1. Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.; 2. NUCSER, KS Hegde Medical Academy, Nitte University, Mangalore-18, Karnataka, India.; Harvard Medical School, UNITED STATES, |
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| Abstract: | Global spectrum of CNVs is required to catalog variations to provide a high-resolution on the dynamics of genome-organization and human migration. In this study, we performed genome-wide genotyping using high-resolution arrays and identified 44,109 CNVs from 1,715 genomes across 12 populations. The study unraveled the force of independent evolutionary dynamics on genome-organizational plasticity across populations. We demonstrated the use of CNV tool to study human migration and identified a second major settlement establishing new migration routes in addition to existing ones. |
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