小儿豉翘清热颗粒联合奥司他韦对急性上呼吸道感染患儿血清炎性因子和外周血T淋巴细胞亚群的影响

摘要 目的：探讨小儿豉翘清热颗粒联合奥司他韦对急性上呼吸道感染患儿血清炎性因子和外周血T淋巴细胞亚群的影响。方法：选择2019年9月至2022年1月期间合肥市第二人民医院收治的急性上呼吸道感染患儿180例。按照双色球法将患儿分为对照组和研究组，在常规治疗的基础上，对照组（给予磷酸奥司他韦颗粒治疗）和研究组（给予小儿豉翘清热颗粒联合磷酸奥司他韦颗粒治疗），两组各为90例。对比两组疗效、临床症状缓解情况、T淋巴细胞亚群指标、炎性因子水平和不良反应发生情况。结果：研究组的临床总有效率为95.56%，高于对照组的83.33%（P<0.05）。研究组的咳嗽、发热、咽痛、鼻塞流涕等症状缓解时间均短于对照组（P<0.05）。治疗5 d后，研究组CD3⁺、CD4⁺、CD4⁺/CD8⁺高于对照组，CD8⁺低于对照组（P<0.05），研究组血清降钙素原（PCT）、白介素6（IL-6）、血清淀粉样蛋白A（SAA）、超敏C反应蛋白（hs-CRP）低于对照组（P<0.05）。两组不良反应发生率组间对比无明显差异（P>0.05）。结论：奥司他韦联合小儿豉翘清热颗粒治疗急性上呼吸道感染，可提高患儿的免疫力，降低血清PCT、IL-6、SAA、hs-CRP水平，有助于临床症状改善。

Effects of Xiaoer Chiqiao Granule Combined with Ostativavir on Serum Inflammatory Factors and Peripheral Blood T Lymphocyte Subsets in Children with Acute Upper Respiratory Tract Infection

ABSTRACT Objective: To investigate the effect of Xiaoer Chiqiao granule combined with oseltamivir on serum inflammatory factors and peripheral blood T lymphocyte subsets in children with acute upper respiratory tract infection. Methods: 180 cases of children with acute upper respiratory tract infection who were admitted to our hospital from September 2019 to January 2022 were selected. The children were divided into the control group and the study group, On the basis of conventional treatment, the control group (treated with oseltamivir phosphate granule) and the study group (treated with Xiaoer Chiqiao granule combined with oseltamivir phosphate granule), 90 cases in each group. The efficacy, remission of clinical symptoms, T lymphocyte subsets indexes, inflammatory factors levels and adverse reactions were compared in the two groups. Results: The total effective rate in the study group was 95.56%, which was higher than 83.33% in the control group (P<0.05). The remission time of cough, fever, sore throat, stuffy nose and runny nose in the study group were shorter than those in the control group(P<0.05). 5 d after treatment, CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in the study group were higher than those in the control group, and CD8⁺ was lower than that in the control group(P<0.05), the serum procalcitonin (PCT), interleukin-6 (IL-6), amyloid A (SAA) and high sensitivity C-reactive protein (hs-CRP) in the study group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions in the two groups (P>0.05). Conclusion: The combination of oseltamivir and Xiaoer Feiqiao Qingre Granule in the treatment of acute upper respiratory tract infection can improve the immunity of children, reduce the levels of serum PCT, IL-6, SAA and hs CRP, and help improve clinical symptoms.