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Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection
Authors:Dan Elgrabli  Remy Beaudouin  Nawel Jbilou  Magali Floriani  Alexandre Pery  Fran?oise Rogerieux  Ghislaine Lacroix
Institution:1. Institut National de l''Environnement Industriel et des Risques (INERIS), Parc technologique Alata, Verneuil en Halatte, France.; 2. Laboratoire Matières et systèmes complexes, UMR7057 CNRS/Université paris Diderot, Paris, France.; 3. Institut de Radioprotection et de Sûreté Nucléaire Cadarache (IRSN), Saint Paul les Durance, France.; Brandeis University, UNITED STATES,
Abstract:Titanium dioxide (TiO2) nanoparticles are used in many applications. Due to their small size, easy body penetration and toxicological adverse effects have been suspected. Numerous studies have tried to characterize TiO2 translocation after oral, dermal or respiratory exposure. In this study, we focused on TiO2 nanoparticle biodistribution, clearance and toxicological effects after intravenous injection, considering TiO2 translocation in the blood occurs. Using ICP-OES, transmission electron microscopy, and histological methods, we found TiO2 accumulation in liver, lungs and spleen. We estimated TiO2 nanoparticles’ half life in the body to about 10 days. Clinical biomarkers were also quantified for 56 days to identify potential toxicological impact on lungs, blood, liver, spleen and kidneys. Results showed absence of toxicological effects after TiO2 intravenous injection at concentrations of 7.7 to 9.4 mg/kg.
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