Maturation of Human Herpesvirus 6A Glycoprotein O Requires Coexpression of Glycoprotein H and Glycoprotein L |
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| Authors: | Huamin Tang Nora F. Mahmoud Yasuko Mori |
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| Affiliation: | aDivision of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, Japan;bFaculty of Pharmacy, Suez Canal University, Ismailia, Egypt |
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| Abstract: | Glycoprotein O (gO) is conserved among betaherpesviruses, but little is known about the maturation process of gO in human herpesvirus 6 (HHV-6). We found that HHV-6 gO maturation was accompanied by cleavage of its carboxyl terminus and required coexpression of gH and gL, which promoted the export of gO out of the endoplasmic reticulum (ER). Finally, we also found that gO was not required for HHV-6A growth in T cells. |
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