A New Clinical Prediction Criterion Accurately Determines A Subset of Patients with Bilateral Primary Aldosteronism Before Adrenal Venous Sampling |
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| Institution: | 1. From the Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia;2. Clinical Radiology Institute, University Medical Centre Ljubljana, Ljubljana, Slovenia;3. University Rehabilitation Institute, Ljubljana, Slovenia;4. FAMNIT, University of Primorska, Koper, Slovenia.;1. From the Department of Endocrinology and Metabolism, Sisli Etfal Training and Research Hospital, Istanbul, Turkey;2. Department of Endocrinology and Metabolism, Namik Kemal University, Faculty of Medicine, Tekirdag, Turkey;3. Department of Radiology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.;1. University of Illinois Undergraduate College, Chicago, Illinois;2. Department of Medicine, University of Illinois Medical Center;3. Department of Medicine, Jesse Brown VA Medical Center, Chicago, Illinois |
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| Abstract: | Objective: Adrenal venous sampling (AVS) is the only available method to distinguish bilateral from unilateral primary aldosteronism (PA). AVS has several drawbacks, so it is reasonable to avoid this procedure when the results would not affect clinical management. Our objective was to identify a clinical criterion that can reliably predict nonlateralized AVS as a surrogate for bilateral PA that is not treated surgically.Methods: A retrospective diagnostic cross-sectional study conducted at Slovenian national endocrine referral center included 69 consecutive patients (mean age 56 ± 8 years, 21 females) with PA who underwent AVS. PA was confirmed with the saline infusion test (SIT). AVS was performed sequentially during continuous adrenocorticotrophic hormone (ACTH) infusion. The main outcome measures were variables associated with nonlateralized AVS to derive a clinical prediction rule.Results: Sixty-seven (97%) patients had a successful AVS and were included in the statistical analysis. A total of 39 (58%) patients had nonlateralized AVS. The combined criterion of serum potassium ≥3.5 mmol/L, post-SIT aldosterone <18 ng/dL, and either no or bilateral tumor found on computed tomography (CT) imaging had perfect estimated specificity (and thus 100% positive predictive value) for bilateral PA, saving an estimated 16% of the patients (11/67) from unnecessary AVS. The best overall classification accuracy (50/67 = 75%) was achieved using the post-SIT aldosterone level <18 ng/dL alone, which yielded 74% sensitivity and 75% specificity for predicting nonlateralized AVS.Conclusions: Our clinical prediction criterion appears to accurately determine a subset of patients with bilateral PA who could avoid unnecessary AVS and immediately commence with medical treatment.Abbreviations:ACTH = adrenocorticotrophic hormoneARR = aldosterone-to-renin ratioAVS = adrenal venous samplingBP = blood pressureCT = computed tomographyeGFR = estimated glomerular filtration rateMR = magnetic resonancePA = primary aldosteronismPRA = plasma renin activityROC = receiver operating characteristicSIT = saline infusion test |
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