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Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain |
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| Authors: | John S. Tokarski Adriana Zupa-Fernandez Jeffrey A. Tredup Kristen Pike ChiehYing Chang Dianlin Xie Lihong Cheng Donna Pedicord Jodi Muckelbauer Stephen R. Johnson Sophie Wu Suzanne C. Edavettal Yang Hong Mark R. Witmer Lisa L. Elkin Yuval Blat William J. Pitts David S. Weinstein James R. Burke |
| Affiliation: | From the Departments of ‡Molecular Structure and Design.;§Immunosciences Biology.;¶Protein Science.;**Leads Discovery and Optimization, and ;‡‡Discovery Chemistry, Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543 and ;the ‖Department of Leads Discovery and Optimization, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492 |
| Abstract: | |
| Keywords: | Allosteric Regulation Janus Kinase (JAK) Molecular Pharmacology Signal Transduction Structural Biology Pseudokinase |