鞘氨醇单胞菌的研究进展

鞘氨醇单胞菌(Sphingomonas)不仅细胞膜含有比脂多糖更疏水的鞘糖脂，而且具有高效的代谢调控机制和基因调控能力，使其在威兰胶合成、环境修复和促进植物生长等方面具有巨大的应用潜力。目前国内在鞘氨醇单胞菌代谢机制方面的研究尚无新突破。本文主要综述了鞘氨醇单胞菌的系统分类、基因组学、基因调控机制及其应用等方面的研究，从基因层面分析鞘氨醇单胞菌产威兰胶的合成机制，为后续鞘氨醇单胞菌高密度发酵、工业化生产等研究提供理论基础，以便进一步发掘其在生物技术上的应用潜力。

Research progress of Sphingomonas

The cell membrane of Sphingomonas contains glycosphingolipids, which is more hydrophobic than lipopolysaccharide. In addition, since Sphingomonas has efficient metabolic regulation mechanism and gene regulation ability, it has significant application potential in welan gum synthesis, environmental remediation, and promotion of plant growth. However, research on genomics in China has not been paid enough attention, resulting in no breakthrough in the research on the metabolic mechanism of Sphingomonas. Therefore, this paper reviewed the systematic classification, genomics, metabolic regulation mechanism, and application of Sphingomonas and analyzed the metabolic mechanism of welan gum produced by Sphingomonas from the genetic level, providing a theoretical basis for the subsequent studies on high-density fermentation and industrial production of Sphingomonas, and thereby further developing its potential application in biotechnology.