Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells |
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| Authors: | Esen M Schreiner B Jendrossek V Lang F Fassbender K Grassmé H Gulbins E |
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| Affiliation: | (1) Department of Physiology, University of Tübingen, Gmelinstrasse 5, 72076 Tübingen, Germany;(2) Department of Neurology, University of Heidelberg/Mannheim, Theodor Kutzer Ufer, 68135 Mannheim, Germany;(3) Department of Immunology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA;(4) Department of Immunology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA |
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| Abstract: | Staphylococcus aureus plays an important role in sepsis, pneumonia and wound infections. Here, we demonstrate that infection with several S. aureus strains results in apoptosis of human endothelial cells. S. aureus induced an activation of cellular caspases, the acid sphingomyelinase, a release of cytochrome c and a stimulation of Jun NH2-terminal kinase (JNK). The significance of these findings is indicated by a prevention of S. aureus triggered apoptosis of human cells deficient for ASM or upon genetic or pharmacological inhibition of JNK or caspases, respectively. |
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| Keywords: | acid sphingomyelinase apoptosis caspases endothelial cells JNK S. aureus |
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