Corticotropin-releasing factor has an anxiogenic action in the social interaction test |
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| Authors: | A J Dunn S E File |
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| Institution: | 1. Department of Surgery – Transplant Surgery, Rush University Medical Center, 1653, W. Congress Pkwy Jelke Building 7th Floor, 60612, Chicago, IL, USA;2. Department of Experimental Surgery, Academic Medical Center, Amsterdam, The Netherlands;3. Institute of Physiology, Center for Integrative Human Physiology, University of Zurich, Winterthurerstr. 190, 8057, Zurich, Switzerland;4. Cantonal Hospital Winterthur, Brauerstr. 15, 8401, Winterthur, Kanton Zurich, Switzerland;1. Neuroendocrine Unit (IMBICE, CONICET-CICPBA), La Plata, Argentina;2. Institute of Veterinary Sciences (ICIVET-Litoral), UNL/CONICET, Santa Fe, Argentina;3. Centre for Experimental & Applied Endocrinology (CENEXA, UNLP-CONICET La Plata), Argentina;1. Department of Theoretical Physics and Quantum Technology, National University of Science & Technology (MISIS), Moscow 119049, Russian Federation;2. Materials Modeling and Development Laboratory, National University of Science & Technology (MISIS), Moscow 119049, Russian Federation;3. Institute for Spectroscopy RAS, 142190 Troitsk, Moscow, Russian Federation;4. Moscow Institute of Physics and Technology (State University), 141700 Dolgoprudny, Moscow Region, Russian Federation |
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| Abstract: | The effects of intracerebroventricular (icv) injections of corticotropin-releasing factor (CRF, 100 and 300 ng) were investigated in the social interaction test of anxiety in rats. Both doses of CRF significantly decreased active social interaction without a concomitant decrease in locomotor activity. CRF also significantly increased self-grooming, an effect that was independent of the decrease in social interaction. These results indicate an anxiogenic action for CRF. Chlordiazepoxide (CDP, 5 mg/kg ip) pretreatment reversed the anxiogenic effects of icv CRF (100 ng), but CRF did not prevent the sedative effects of CDP. There were no statistically significant changes due to CRF in locomotor activity or rears or head dipping in the holeboard test. Both doses of CRF significantly increased plasma concentrations of corticosterone. The possible mechanisms of the behavioral effects of CRF are discussed. |
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