LTR Retrotransposon-Gene Associations in Drosophila melanogaster |
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| Authors: | Eric W Ganko Casey S Greene Judson A Lewis Vikram Bhattacharjee John F McDonald |
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| Institution: | (1) Department of Genetics, University of Georgia, Athens, GA 30602, USA;(2) School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA;(3) Department of Biology, CB 3280, University Carolina at Chapel Hill, NC 27599, USA |
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| Abstract: | Thirty-three percent (228/682) of all long terminal repeat (LTR) retrotransposon sequences (LRSs) present in the sequenced
Drosophila melanogaster genome were found to be located in or within 1000 bp of a gene. Recently inserted LTR retrotransposons are significantly
more likely to be located in or within genes than are older, fragmented LTR retrotransposon sequences, indicating that most
LRS-gene associations are selected against over evolutionary time. LRSs associated with conserved genes (homologenes) are
especially prone to negative selection. In contrast, fragmented LRSs that have persisted in the genome over long spans of
evolutionary time are preferentially associated with genes involved in signal transduction and other newly evolved functions.
Reviewing Editor: Dr. Juergen Brosius |
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| Keywords: | Drosophila melanogaster LTR retrotransposon Gene evolution Genome evolution Transposable element |
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