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Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors |
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| Authors: | Sakamoto Jun-Ichi Koyama Tetsuo Miyamoto Daisei Yingsakmongkon Sangchai Hidari Kazuya I P J Jampangern Wipawee Suzuki Takashi Suzuki Yasuo Esumi Yasuaki Hatano Ken Terunuma Daiyo Matsuoka Koji |
| Affiliation: | Division of Materials Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan. |
| Abstract: | An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with alpha-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases. |
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