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Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines |
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| Authors: | Weterings Jimmy J Khan Selina van der Heden Gerbrand J Drijfhout Jan W Melief Cornelis J M Overkleeft Herman S van der Burg Sjoerd H Ossendorp Ferry van der Marel Gijsbert A Filippov Dmitri V |
| Institution: | Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands. |
| Abstract: | The preparation of three different 2-alkoxy-8-hydroxyadenylpeptide conjugates has been accomplished by solid-phase synthesis combined with 'on-resin' Cu(I) catalyzed Huisgen cycloaddition. The immunogenicity of the compounds has been evaluated in IL-12 production and antigen presentation assays. |
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