抗—HEV的临床意义

为了探索散发性戊型肝炎抗体的临床意义.采用ELISA方法检测.结果为102份抗-HEV阳性血清中抗-HEV·IgM+72份(占70.6%)、IgG+21份(占20.6%)、双阳性9份(占8.8%);IgM阳性与急性期病程和ALT异常呈现正相关.认为抗-HEV·IgM/IgG临床判断IgM为诊断标志、IgG为感染标志;疫区急性期内再感染可能性极少;城市散发戊肝食源性感染是主要传播方式之一;提示应加强饮食服务卫生管理.

Clinical significance of Anti-HEV antibodies

To explore the clinical significance of antibodies in sporadic Hepatitis E virus infected patients,a ELISA protocol was used in this study.Of the 102 serum samples with anti HEV antibody positive 72 (70.6%) were anti HEV IgM,21 (20.6%) were anti HEV IgG,and 9 (8.8%) were positive for both anti HEV IgM and IgG.Most of the positive IgM occured in the acute phase of Hepatitis E,Which was closely related to ALT abnormality.The clinical significance of anti HEV IgM and IgG was that the positive IgM had diagnostic value and the positive IgG only indicatd infection.Reinfection seldom happened during the acute phase in the epidemic stricken area.Sporadic city epidemic was mainly food borne related It indicated that the management and control measures should be strengthened in diatetic hygiene in food service.