Approaches for calculating power for case-cohort studies |
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Authors: | Kim Mimi Y Xue Xiaonan Du Yunling |
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Institution: | Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA. mikim@aecom.yu.edu |
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Abstract: | An approach for determining the power of a case-cohort study for a single binary exposure variable and a low failure rate was recently proposed by Cai and Zeng (2004, Biometrics 60, 1015-1024). In this article, we show that computing power for a case-cohort study using a standard case-control method yields nearly identical levels of power. An advantage of the case-control approach is that existing sample size software can be used for the calculations. We also propose an additional formula for computing the power of a case-cohort study for the situation when the event is not rare. |
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