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Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers |
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| Authors: | Blizzard Timothy A Dininno Frank Morgan Jerry D Chen Helen Y Wu Jane Y Kim Seongkon Chan Wanda Birzin Elizabeth T Yang Yi Tien Pai Lee-Yuh Fitzgerald Paula M D Sharma Nandini Li Ying Zhang Zhoupeng Hayes Edward C Dasilva Carolyn A Tang Wei Rohrer Susan P Schaeffer James M Hammond Milton L |
| Affiliation: | Merck Research Laboratories, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com |
| Abstract: | A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue. |
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