Penicillin acylase catalysis in the presence of ionic liquids |
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| Authors: | Wei-Guo Zhang Dong-Zhi Wei Xue-Peng Yang Qing-Xun Song |
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| Institution: | (1) State Key Laboratory of Bioreactor Engineering, Institute of New World Biotechnology, East China University of Science and Technology, Shanghai, 200237, China |
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| Abstract: | Several ionic liquids were used as reaction media for penicillin G acylase catalysis. In all the assayed ionic liquids, bmim]PF6 proved good media for PGA-catalyzed hydrolysis. A novel bmim]PF6/water two-phase system is provided for 6-aminopenicillanic acid (APA) production, which will be more benefical than aquous batch systems used widely in industrial production of APA. |
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| Keywords: | Ionic liquids Penicillin acylase Enzyme stability |
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