Localization of human cardiac beta-myosin heavy chain gene (MYH7) to chromosome 14q12 by in situ hybridization |
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| Authors: | H Qin J Kemp M Y Yip P R Lam-Po-Tang J F Hoh B J Morris |
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| Affiliation: | Department of Physiology, University of Sydney, N.S.W., Australia. |
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| Abstract: | The genes coding for each human cardiac myosin heavy chain (alpha-MHC and beta-MHC, MYH6 and MYH7, respectively) are tightly linked and the alpha-MHC gene has been assigned to chromosome 14. In order to provide a more precise regional localization, in situ hybridization experiments were carried out using a 3H-labeled probe derived from a beta-MHC genomic clone. The results demonstrated that the human cardiac MHC genes are located within the q12 band of chromosome 14. |
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