多囊卵巢综合征患者与健康人群肠道菌群差异性分析

目的 比较多囊卵巢综合征(PCOS)患者与健康人群间肠道菌群的差异,为后续研究提供参考.方法 采用16SrDNA扩增子测序法对30例PCOS患者(PCOS组)和20例健康人(健康组)粪便标本中菌群结构进行分析,并比较两组之间的区别.结果 与健康组相比,PCOS组患者肠道菌群α多样性降低.PCOS组患者肠道厚壁菌门(Fi...

Intestinal flora differences between polycystic ovary syndrome patients and healthy people

Objective To compare the differences in intestinal flora between patients with polycystic ovary syndrome (PCOS) and healthy people and provide reference for follow up research. Methods The 16S rDNA amplicon sequencing method was used to analyze the differences in intestinal flora between the two groups (PCOS group and healthy control group). Results Compared with the healthy control group, the alpha diversity of the intestinal flora in PCOS group was lower. The abundance of Firmicutes and Actinobacteria was higher than that of the healthy group, and the abundance of Bacteroidetes was lower than that of the healthy group (all P0.05). The abundances of intestinal Proteobacteria, Bacillus and Colibacillus were higher, while that of Bacteroidia was lower in PCOS group than in healthy control group respectively (all P0.05). Conclusion The patients with polycystic ovary syndrome have imbalance of intestinal flora which may be a potential risk factor for PCOS.