芽胞杆菌治疗幽门螺杆菌感染疗效的Meta分析

目的 评价芽胞杆菌(Bacillus)联合根除标准疗法治疗幽门螺杆菌(H.pylori)感染的有效性。 方法 收集关于芽胞杆菌联合治疗H.pylori感染的随机对照试验(RCT),检索时限为建库至2020年5月；对符合纳入标准的研究进行偏倚风险评价及Meta分析。 结果 最终纳入14个RCT。Meta分析结果显示芽胞杆菌联合治疗能提高H.pylori根除率(ITT分析:RR=1.13,95% CI:1.08~1.18,P结论 芽胞杆菌联合疗法能有利于提高H.pylori根除率,并降低总不良反应的发生,相对于标准疗法有一定的意义。

The efficacy of Bacillus in the treatment of Helicobacter pylori infection:a meta analysis

Objective To evaluate the effectiveness of Bacillus combined with standard therapies in the treatment of H.pylori infection. Methods Databases were searched from inception to May 2020 and randomized controlled trials (RCTs) on Bacillus combined treatment of H.pylori infection were collected. RevMan 5.3 software were used for analysis after screening the literature, extracting data, and evaluating quality according to the inclusion and exclusion criteria. Results A total of 14 RCTs were finally included. Bacillus combined with standard regimens raised the eradication rate of H.pylori (ITT analysis:RR=1.13,95% CI:1.08 1.18, PConclusion Bacillus combined with standard regimens can raise the eradication rate of H.pylori while decrease the adverse effect, which has clinical significance in the treatment of H.pylori infection.