不同脑卒中风险中老年人群肠道菌群的差异

目的 研究不同脑卒中风险中老年人群肠道菌群的差异,为后续研究提供参考.方法 选取2017年2月至2019年2月来我院接受检查的中老年脑卒中风险者126例,根据不同卒中风险程度分为低危组(48例)、中危组(45例)、高危组(33例);同时进行认知功能筛查,选出轻度认知功能障碍患者35例为轻度障碍组,剩余91例认知功能正常...

The intestinal flora differences among middle aged and elderly populations with different stroke risks in community

Objective To investigate the differences in intestinal flora among middle aged and elderly populations with different stroke risks, and provide a reference for the following study. Methods A total of 126 middle aged and elderly patients at risk of stroke underwent examination in our hospital from February 2017 to February 2019 were selected and divided into low risk group (n=48), medium risk group (n=45) or high risk group (n=33) according to risk classifications of stroke. The cognitive function of all patients was assessed, including 35 patients with mild cognitive impairment and 91 patients with normal residual cognitive function (control group). Fecal samples were collected, and bacterial DNA was extracted, then the composition of intestinal flora was analyzed. The contents of short chain fatty acids were compared among patients with different stroke risks. Results The intestinal flora in the low risk group were mainly composed of Ruminococcus, Clostridium leptum, Lachnospiraceae, Rothia and Butyrivibrio, those in the medium risk group were composed of Veillonellaceae, Enterobacteriaceae and Lactobacillaceae, while those in the high risk group was mainly composed of Veillonellaceae and Enterobacteriaceae. The abundances of Ruminococcus, Lachnospiraceae and Prevotellaceae in the low risk group were significantly higher than those in the medium risk group, while those of Enterobacteriaceae, Veillonellaceae, Clostridium and Streptococcaceae in the low risk group were significantly lower than in the other two groups (all PConclusion The intestinal flora have significant differences among middle aged and elderly populations with different stroke risks and with different degrees of cognitive dysfunction.