Wnt signaling in breast organogenesis |
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| Authors: | Kata Boras-Granic and John J Wysolmerski |
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| Institution: | Section of Endocrinology and Metabolism; Department of Internal Medicine; Yale University; New Haven, Connecticut USA |
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| Abstract: | Wnt signals play a critical role in regulating the normal development of the mammary gland and dysregulation of Wnt signaling causes breast cancer. This pathway is involved in the earliest development of the mammary gland in embryos and its role extends through the functional differentiation of the gland during pregnancy. In this review, we summarize the molecular mechanisms through which Wnts regulate mammary gland development in the mouse.Key words: Wnt, mammary gland, embryo, postnatal, cancer, stem cell |
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