Tat-SIRT1 tango |
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Authors: | Blazek Dalibor Peterlin B Matija |
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Institution: | Structural Biology Program, Sloan-Kettering Institute, New York, NY 10021, USA. |
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Abstract: | In this issue of Molecular Cell, Meulmeester et al. (2008) identify USP25 as a SUMO2/3-interacting protein and substrate. A USP25 SUMO interaction motif directs SUMO2/3 specificity, and SUMO modification diminishes USP25's ability to bind and degrade polyubiquitin chains. |
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