Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis |
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| Authors: | Mori H Kawabata K Matsunaga K Ushida J Fujii K Hara A Tanaka T Murai H |
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| Affiliation: | Department of Pathology, Gifu University School of Medicine, Japan. |
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| Abstract: | Polyphenolic compound chlorogenic acid (CGA) known to be much contained in coffee beans was found to have a regressive effect on induced aberrant crypt foci (ACF) as well as on development of ACF in azoxymethane (AOM)-induced colorectal carcinogenesis in rats. Rice germ and gamma-aminobutyric acid-enriched defatted rice germ inhibited AOM-induced ACF formation and colorectal carcinogenesis in rats. Ferulic acid (FA) also known to be contained in coffee beans and rice prevented AOM-induced ACF formation and intestinal carcinogenesis in rats. Both of food factors, coffee and rice may be of benefit to prevention of human colorectal cancers. |
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